Sale worked five innings, allowing nine hits and seven runs with six strikeouts.
Chris Sale has given up back-to-back home runs to Alex Bregman and Jose Altuve as the Astros jump out to the quick 2-0 lead.
The Astros have shown why they led the majors in runs, pounding the Red Sox by twin scores of 8-2.
Altuve (3-for-4, three RBIs) became the first player in franchise history to homer three times in a postseason game, doing so twice off Sale (0-1). But two of those comebacks - in 1999 and 2003 - have been turned in by the Red Sox, who also came back from 0-3 to win the 2004 ALCS against the New York Yankees.
The stakes: The Red Sox entered the season with a super-rotation of Chris Sale, David Price and 2016 Cy Young victor Rick Porcello, so, of course, with their season on the line, they turn to a starter they claimed on waivers in June.
Pitching ace Justin Verlander and the Houston Astros play host to the Boston Red Sox on Thursday in Game 1 of their American League Division playoffs.
Springer though had a solo shot off Pomeranz and at that point game the Astros a 3-1 lead. He drilled a ball opposite field off the right-center wall to score two runs, putting the Astros up 4-2.
As for the lineup against Astros right-hander Brad Peacock, Farrell said the Red Sox would go with the one they used all year against righties, with Hanley Ramirez at first, Dustin Pedroia at second, Rafael Devers at third. Altuve's partner in crime, shortstop Carlos Correa, continued where the second baseman left off, homering, doubling and knocking in four runs Friday to put the Red Sox on the brink of elimination.
George Springer hit his first postseason home run to make it 3-1 before Altuve made it 4-1 with an RBI single later in the inning. If things go all the way, then Game 5 will bring the series back to Houston for the victor takes all decider next Wednesday. The same can be said for Dallas Keuchel.
The stakes: Home teams that win the first two games of a best-of-five series are 38-6 in taking the series, so it's not impossible for the Yankees to pull off a comeback. Fox Sports 1 will broadcast the game live.
Allen came in with two on and two outs in the eighth to face Judge, who struck out for the fourth time and the rookie angrily snatched at his bat in frustration. After what we've seen through two afternoons of baseball in downtown Houston, it feels safe to say they're at their best right now.
Coming into this series, Doug Fister was the only pitcher on the Red Sox with a postseason victory. "It seemed easy for awhile with the Tigers organization, especially going my first year to the World Series, so I appreciate every step of the way now even more, I think".
In three career appearances (two starts) against Boston, Keuchel has a 9.88 ERA-not exactly something for Houston fans to get excited about.
Despite his poor start on Thursday, it's entirely likely that Sale could be pressed back into service later in the series on short rest given the rotation's uncertainty in recent weeks.
The bullpen has been one of the Red Sox' major strengths throughout the season and the team would be wise to ease the load on the Game 3 starter by leaning on relief pitchers.