Ashley Young was the first of the Red Devils' long term absentees to return, but Marcos Rojo is still out.
Koeman claimed victories over Louis van Gaal's United in January 2015 and 2016 with Southampton, while only a last-gasp Zlatan Ibrahimovic penalty against Everton in April denied him a hat-trick of Old Trafford wins.
But the spotlight will be fixed on Rooney, who left United following a successful 13-year career that saw him become the club's record goalscorer.
Speaking about another of his current group of players, the Portuguese confirmed that Paul Pogba will definitely miss Sunday's game against Everton after the French midfielder picked up a hamstring injury against FC Basel on Tuesday night.
Everton have been a bit inconsistent this season, as they have mixed some impressive displays with some really poor ones.
Antonio Valencia and Matteo Darmian will push to play in the full-back roles after the defence received a complete overhaul in midweek. He faces competition from Ander Herrera and club captain Michael Carrick, though.
"I feel good and I feel my movements are there".
Up front, Romelu Lukaku continues to plunder goals and, against his old club, will be looking to extend his purple patch.
The Belgian worldwide would provide United with plenty of steel in the middle of the park alongside Nemanja Matic. Meanwhile, midfielders Ross Barkley (hamstring) and James McCarthy (knee) are likely to be out as well. I just know from experience it's a muscular injury.
Ronald Koeman will be without Ross Barkley, Funes Mori, Yannick Bolasie and Seamus Coleman for the clash against the Red Devils as they are all out with injuries.
United entertain Everton at Old Trafford on Sunday afternoon, hoping to maintain their unbeaten start to the season and remain top of the Premier League in the process. Many people (including me, I must admit) thought there'd be a reaction at Atalanta in the Europa League.
"That is an opportunity for others and the others are ready to get that opportunity, and to perform", Jose stated.