Throughout the show, the likes of Oprah Winfrey, Justin Bieber, Uzo Aduba, Nicki Minaj, Jon Stewart, Kerry Washington, Reese Witherspoon, and many, many more answered phones to take donations from callers.
Online donations are also accepted at handinhand2017.com. "With something in the disease-related community, you go: 'I hope this helps.' This one, you go: 'Oh, it's going to help'".
If you're eager to share your dollars or want to tune in, we've prepared a handy guide for you.
"Natural disasters don't discriminate", Beyonce said.
Following Beiber's segment, Tori Kelly and Luis Fonsi sang a lovely bilingual rendition of "Hallelujah". The 49-year-old Julia and the 56-year-old George both donned black blazers for the fundraiser, which was simultaneously broadcast on ABC, NBC, CBS, Fox, CMT, and Twitter.
The event is sponsored by the Michael & Susan Dell Foundation, Verizon, Apple, Albertsons Companies Foundation, Merck and Paypal and is a program of Comic Relief, Inc. For numerous stars, the storms hit close to home. I've been on the road.
"Helpless - helpless is an understatement", Fonsi added of being on tour and unable to be with his family.
"We've come together today to love on the people that have been devastated by the hurricanes". Proceeds will benefit Rebuild Texas Fund, Feeding Texas, Feeding Florida, Habitat for Humanity, Save the Children, American Society for the Prevention of Cruelty to Animals, and United Way of Greater Houston.