"We can not come to a unanimous consensus on any of the counts", O'Neill read.
At the end of the day on Thursday, jurors have deliberated for more than 40 hours this week.
The panel, which has now considered the comic's fate for a whopping 41-hours, were ordered to return to court at 9:00 a.m. Friday morning to resume discussion.
O'Neill told jurors Thursday night, "I am proud of each and every one of you ... this is hard work you are doing".
"I want to reiterate how proud I am of each and every one of you", O'Neill said as he sent the jury back to the hotel.
"I will not set any specific time for continuation of deliberations", he said, according to the Los Angeles Times.
Cosby, of Cheltenham, has been on trial for nine days and charged with three counts of aggravated indecent assault.
The three charges accuse Cosby of assaulting Andrea Constand without her consent, assaulting her when she was unconscious and assaulting her using drugs to substantially impair her ability to consent.
The jury will emerge from deliberations whenever they decide whether to send Cosby to prison for as many as 10 years.
This is published unedited from the IANS feed. One, who would only give his first name as Garvey, said this was about race - a number of Cosby's accusers are black.
Cosby, the 79-year-old entertainer once beloved for his brand of family-friendly comedy, is accused of drugging and sexually assaulting Constand, then 31, at his home near Philadelphia in 2004.
In 1995, it took a Los Angeles jury four hours to acquit American football star O.J. Simpson of murdering his ex-wife Nicole Brown and her friend Ron Goldman.
Retrial would be costly, she said, and she worries that further dragging out Cosby's prosecution might push it out of the realm of public concern. The charges stem from a 2004 sexual encounter with Constand.
If the panel can't break the deadlock, the judge could declare a hung jury and a mistrial. Jurors need to reach a unanimous agreement on some or all of the counts in order to reach a verdict and convict Cosby or find him innocent. "If she insists, that could hold some weight", he said.
Bill Cosby, the comedian who was once known as America's family man and role model, is now awaiting the decision of the jury regarding his highly publicized rape case.
The case has already helped demolish his nice-guy reputation as America's Dad.
The jurors on Wednesday requested part of Constand's testimony, particularly about the night of the alleged assault, as well as testimony from a law enforcement officer who had interviewed Cosby about the incident.
Throughout the week of deliberation, the jury paused at least six times to review key evidence - including Cosby's admission that he did indeed fondle Constand after giving her pills. One slunk down in his seat, looking angry. A toxicologist called to testify by prosecutors said Benadryl had been used by a serial rapist in Great Britain, and that Cosby gave Constand enough of the medication - 1 1/2 pills - to make her drowsy.
He did not take the stand in his sexual assault trial.